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盐酸托可卡因

Tropacocaine HCl properties

代名词： NSC 76018
CAS编号： 637-23-0
公式： 碳 15 哈 19 不 2  • 盐酸
摩尔质量： 281.8
纯度： >98%

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* 本页信息仅为摘要，并非涵盖此药物的所有可用信息。本信息并未涵盖所有可能的用途、用法、注意事项、药物相互作用或不良反应，亦不能替代您的医疗保健专业人员的专业知识和判断。

Product Definition: Tropacocaine HCl (Research Chemical)

化学名称：  Tropacocaine hydrochloride
同义词：  Tropacocaine HCl, Benzoylecgonine methyl ester
分子式：  C₁₅H₁₉NO₂•HCl
分子量：  281.78 g/mol
CAS No.:  537-26-8
外貌：  白色结晶粉末
纯度：  ≥98% (HPLC verified)
溶解度：  50毫克/毫升水溶液

Description & Pharmacology:
Tropacocaine is a naturally occurring cocaine analog with:
✔Local anesthetic effects
✔Stimulant properties
✔Shorter duration of action than cocaine (1-2 hours)
✔More selective noradrenaline reuptake inhibition

Research applications:

  1. Neuroscience research:

    • 多巴胺转运体研究

    • Comparative pharmacology of stimulants

  2. Medical examination:

    • Local anesthetic mechanisms

    • Vasoconstriction studies

  3. Analytical chemistry:

    • Reference standard for drug analysis

    • Forensic investigation

Benefits for Research:
✅ Naturally occurring compound
✅Less addiction potential than cocaine
✅Good stability in solution
✅Suitable for in vitro receptor studies

Risks & Limitations:
❌ Possible side effects:

  • Tachycardia

  • Hypertension

  • CNS stimulation
    ❌Limited pharmacokinetic data available
    ❌Potential for abuse

Dosage protocol (for research):

应用ConcentrationExpected effect
体外研究1-10 μM受体结合
Local anesthetic test0.1-0.5% solutionNerve block
神经转运体研究5-50 μM多巴胺/去甲肾上腺素效应

Safety measures:

  • Wear appropriate PPE (gloves, lab coat)

  • Work under a fume hood

  • Avoid contact with skin and eyes

  • Do not combine with MAO inhibitors

Frequently Asked Questions:

  1. Is Tropacocaine legal in the Netherlands?
    It may fall under the Opium Act as a cocaine-related substance.

  2. How is it different from cocaine?
    Less euphoric effect, shorter duration of action.

  3. Can it be used as a local anesthetic?
    For research purposes only, not for medical use.

  4. Is it detectable on drug tests?
    It may cross-react with cocaine tests.

Quality Control & Analytical Data:

Specifications:

  • Purity: ≥98% (HPLC)

  • Heavy metals: <1 ppm

  • Loss on drying: <0.5%

  • Residual solvents: <0.1%

Stability data:

  • Shelf life: 36 months at 15-25°C

  • Light sensitivity: Moderate

  • Moisture sensitivity: High

Conclusion:
Tropacocaine HCl is a valuable research substance for pharmacological and analytical studies, but requires responsible use.

⚠ For research purposes only – not for human use

Storage advice:

  • Airtight packaging

  • Store in a dark place

  • Dry at <25°C

Ethical considerations:

  • For use by qualified personnel only

  • Animal testing requires ethical approval

  • Document all experiments accurately