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5-MeO-DMT hydrochloride - Billede 1
5-MeO-DMT hydrochloride - Billede 2

5-MeO-DMT hydrochlorid

5-MeO-DMT hydrochloride properties

Synonym: 5-methoxy-N,N-dimethyltryptaminhydrochlorid
CAS-nummer: efter
Formel: 3-[2-(dimethylamino)ethyl]-5-methoxyindolhydrochlorid
Molær masse: 254,8 g/mol
Renhed: >97%

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5-MeO-DMT Hydrochloride – Scientific Product Documentation

General Description

5-MeO-DMT hydrochloride (5-Methoxy-N,N-dimethyltryptamine HCl) is a water-soluble salt of classical tryptamine, particularly suitable for pharmacological research due to its increased stability and bioavailability compared to the freebase form.

Tekniske specifikationer

ParameterSpecification
Chemical FormulaC₁₃H₁₈N₂O · HCl
Molecular Weight254,75 g/mol
Renhed≥98% (analyzed by HPLC-UV)
AppearanceWhite to light yellow crystalline powder
SolubilityHigh in water (>50 mg/ml), methanol, PBS
Melting point243-247°C (decomposes)
StabilityHygroscopic; store in dry conditions

Videnskabelige anvendelser

1. Neuropharmacology & Behavioral Research

  • Serotonin receptor studies:  Potent 5-HT₁ₐ/₂ₐ agonist with rapid cerebral penetration.

  • Animal experiments (in vivo):  Behavioural paradigms (e.g. head-twitch response in rodents).

  • Electrophysiology:  Effects on neuronal oscillations (e.g., gamma-band activity).

2. Biochemical & Molecular Studies

  • Intracellular signaling:  cAMP accumulation and β-arrestin recruitment assays.

  • Enzyme kinetics:  MAO-A metabolism (IC₅₀ ~2-5 μM).

3. Clinically Relevant Research

  • Dose-response relationships:  Preclinical safety profiling.

  • Comparative pharmacology:  Towards psilocybin, DMT, and other tryptamines.

Experimental Guidelines

Recommended Concentrations

ApplicationConcentration rangeOpløsningsmiddel
Cell cultures (in vitro)1 nM – 10 μMPBS/DMEM (≤0,1% DMSO)
Receptor assays0,1 – 100 μMTris-HCl-buffer (pH 7,4)
Animal studies (ip/iv)0,1 – 5 mg/kgSterile saline solution

Safety measures

  • Personal protection:  Lab coat, gloves (nitrile), safety glasses.

  • Håndtering:  Hygroscopic – close promptly after use.

  • Storage:  Airtight, under argon, at -20°C (prevent hydrolysis).

Stability & Storage

  • Holdbarhed:

    • -20°C:  >2 years (unchanged purity).

    • 4°C:  6 months (in dry environment).

  • Relegation:

    • Hydrolysis on prolonged exposure to moisture (monitor by HPLC).

Analytical Validation

Each batch comes with:

  1. HPLC-UV-kromatogram  (C18 column, retention time ~6.2 min).

  2. MS/MS fragmentation  (characteristic ions: m/z 219 → 174, 160).

  3. Residual solvents  (meet ICH Q3C guidelines).

Legal Status (Netherlands/EU)

  • Narcotics legislation:  Not explicitly mentioned in the Opium Act, but possibly under analogous legislation (Appendix II).

  • Scientific use:  Permit required for institutions (CCMO approval for animal testing).

  • Eksportkontrol:  Subject to EU Regulation 2019/1998 (psychotropic substances).

Ofte stillede spørgsmål (FAQ)

Q1 : What are the advantages of HCl over freebase?

  • Improved solubility  (ideal for injection studies).

  • Longer shelf stability  at room temperature.

Q2: Is 5-MeO-DMT-HCl detectable in drug tests?
A: Yes, via:

  • LC-MS/MS  (recognized as 5-MeO-DMT + HCl adduct).

  • Immunoanalyser:  Cross-reactivity with DMT (~15-20%).

Q3: Are there risks when combining with MAO inhibitors?
EN:  Absolutely.

  • Increased risk of  serotonin syndrome  (avoid combination!).

  • Use only in MAO-free models.

Q4: How to dispose of waste?
EN:

  1. Neutralize with  sodium bicarbonate  (pH-værdi 7-8).

  2. Adsorb with  activated carbon .

  3. Dispose of as  hazardous chemical waste  (UN 3249, Class 6.1).

References & Contact

Core literature:

  1. Shen et al. (2010). “Farmakologi af 5-MeO-DMT-derivater”.  J Psykopharmakol .

  2. Kaasik et al. (2021). “Metaboliske veje for 5-MeO-DMT”.  Xenobiotics .

This product is intended only for authorized scientific research. Not for human consumption or diagnostic use. Please observe local regulations.